There are parallels, I think, between the impact of Europeans on brown bears, and the effects of domestication, particularly on dogs. Both sets of selective pressure have altered the behaviour and diet of the beasts in question. Admittedly, Europe's bears still live in the wild, but an argument can be made that the Europeans have domesticated wild Europe itself. It would be well worthwhile assaying the behaviours, diets and reproductive patterns of Europe's wild animals to determine just how greatly human hunting and habitat alteration have changed them.