"This points to the second possible explanation for the noetic sense: when our sense of a subjective "I" disintegrates, as it often does in a high-dose psychedelic experience (as well as in meditation by experienced meditators), it becomes impossible to distinguish between what is subjectively and objectively true. What's left to do the doubting if not your I? * * * IN THE YEARS following that first powerful psychedelic journey, Bob Jesse had a series of other experiences that shifted the course of his life."