Winfree came from a family in which no one had gone to college. He got started, he would say, by not having proper education. His father, rising from the bottom of the life insurance business to the level of vice president, moved family almost yearly up and down the East Coast, and Winfree attended than a dozen schools before finishing high school. He developed a feeling that the interesting things in the world had to do with biology and mathematics and a companion feeling that no standard combination of the two subjects did justice to what was interesting. So he decided not to take a standard approach. He took a five-year course in engineering physics at Cornell University, learning applied mathematics and a full range of hands-on laboratory styles. Prepared to be hired into military-industrial complex, he got a doctorate in biology, striving to combine experiment with theory in new ways.