"The situation changed for Michael and for millions of other schizophrenics, for better and worse, around 1953, when the first tranquilizer--a drug called Largactil in England, Thorazine in the United States--became available. The tranquilizers could damp down and perhaps prevent the hallucinations and delusions, the "positive symptoms" of schizophrenia, but this could come at great cost to the individual."