"Of course, it is not so easy to "falsify," i.e., to state that something is wrong with full certainty. Imperfections in your testing method may yield a mistaken "no." The doctor discovering cancer cells might have faulty equipment causing optical illusions; or he could be a bell-curve-using economist disguised as a doctor. An eyewitness to a crime might be drunk. But it remains the case that you know what is wrong with a lot more confidence than you know what is right. All pieces of information are not equal in importance. Popper introduced the mechanism of conjectures and refutations, which works as follows: you formulate a (bold) conjecture and you start looking for the observation that would prove you wrong. This is the alternative to our search for confirmatory instances. If you think the task is easy, you will be disappointed--few humans have a natural ability to do this. I confess that I am not one of them; it does not come naturally to me.*"