In this and so many other ways, it seems, the Hopkins psilocybin experience is the artifact not only of this powerful molecule but also of the preparation and expectations of the volunteer, the skills and worldviews of the sitters, Bill Richards's flight instructions, the decor of the room, the inward focus encouraged by the eyeshades and the music (and the music itself, much of which to my ears sounds notably religious), and, though they might not be pleased to hear it, the minds of the designers of the experiments.