The Predators The African lion makes a kill only twice out of every ten hunts. Leopards do better, catching their prey twenty-five percent of the time, and cheetahs do best of all the big cats, with a kill ratio of nearly fifty percent. The deadliest four-legged African predator is not a big cat. It cannot be outrun or outdistanced, its pursuit is relentless, and it captures its prey nine out of every ten hunts. The most dangerous predator in Africa is the wild dog.