The stretch of the Appian Way past the Catacombs of San Sebastiano is the least interesting and most crowded (even dangerous). Avoid it by taking the pedestrian and bike path (open daily except Wed), which begins just past the Catacombs of San Sebastiano, at the intersection with Via delle Sette Chiese. To reach the path, go through the arch at #126. The quiet path parallels the Appian Way and takes you directly to the Catacombs of San Callisto. On Wednesdays, when the gate is closed, you'll have to stay straight on Via Appia Antica, being careful of traffic.