The trauma of Down's syndrome is that it is present prenatally and can therefore undermine the early stages of bonding. The challenge of autism is that it sets in or is detected in the toddler years, and so transfigures the child to whom parents have already bonded. The shock of schizophrenia is that it manifests in late adolescence or early adulthood, and parents must accept that the child they have known and loved for more than a decade may be irrevocably lost, even as that child looks much the same as ever.