"Tranquilizers have little or no effect on the "negative" symptoms of schizophrenia--withdrawal, flattening of affect, etc.--which, in their insidious, chronic way, can be more debilitating, more undermining of life, than any positive symptoms. It is a question of not just medication but the whole business of living a meaningful and enjoyable life--with support systems, community, self-respect, and being respected by others--which has to be addressed. Michael's problems were not purely "medical." --"