When microbes arrived in the Western Hemisphere, he argued, they must have swept from the coastlines first visited by Europeans to inland areas populated by Indians who had never seen a white person. Colonial writers knew that disease tilled the virgin soil of the Americas countless times in the sixteenth century. But what they did not, could not, know is that the epidemics shot out like ghastly arrows from the limited areas they saw to every corner of the hemisphere, wreaking destruction in places that never appeared in the European historical record. The first whites to explore many parts of the Americas therefore would have encountered places that were already depopulated.