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45729ec However, Pauling's interest in these carotenoids and flavonoids was confined to their chemical structures and the influence of structure on optical properties; he did not address their health functions. In 1941 Pauling was diagnosed with Bright's disease, or glomerulonephritis, which was at the time an often-fatal kidney disorder. On the advice of physicians at the Rockefeller Institute, he went to San Francisco for treatment by Thomas Addi.. Andrew W. Saul