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af72f36 Table 2 List of Initiatives: What do I want to accomplish? (State the end result or outcome) When do I want to accomplish it? (Be as specific as you can) Why do I think it is important? (State the difference that you believe it will it make) 1. 2. 3. Jeffrey D. Ford
46e8deb Table 3 For each Initiative: Who needs to participate? (List all individuals and teams) Where will resources come from? How might the work get done? 1. 2. 3. Jeffrey D. Ford
4e4f108 This was a new type of Klan. They were still race haters, but they sold themselves to the populace on the platform of law and order. Imagine. There weren't enough colored people out there on the island for them to get that worked up about, so they kind of transferred their energy into hating the Catholics, the Jews, the immigrants. They were down on what they considered the dissolution of the white race by all of the foreigners coming into .. Jeffrey Ford
d2630c9 Americans so dearly love to be fooled. --Charles Baudelaire Jeffrey Ford
6c2b756 Parents: so essential, yet sometimes like something you've stepped in and cannot get off your shoe. What else is there but to love them? parents Jeffrey Ford
eebb6a3 No man is above justice," George Mason preached at the Constitutional Convention in 1787. That sentiment still rings true, yet competes with the political reality offered by then-representative Gerald Ford, who quipped in 1970 that "an impeachable offense is whatever a majority of the House of Representatives considers it to be at a given moment in history." Jeffrey A. Engel
c8dc83b As we followed him down a hall to a back bedroom, he told us that he owned the house. "Unfortunately, it's not haunted," he said." Jeffrey Ford
23f3a28 We know that ecological isolation--either by seawater or by other sorts of delimitation--correlates strongly with risk of extinction David Quammen
f95d097 He succeeded in staying out of exactly and only those forms of postadolescent trouble that were not winked at, sating himself with those that were. David Quammen
8bc5472 not just Machupo but also Marburg (1967), Lassa (1969), Ebola (1976, with Karl Johnson again prominently involved), HIV-1 (inferred in 1981, first isolated in 1983), HIV-2 (1986), Sin Nombre (1993), Hendra (1994), avian flu (1997), Nipah (1998), West Nile (1999), SARS (2003), and the much feared but anticlimactic swine flu of 2009. David Quammen
b3fd591 aboard: David Quammen
8be733b Without explaining what's on my mind, I ask Nafus and Schreiner: Have they seen any recent invasions by exotic arthropods, or any dramatic population outbreaks among native ones? I inquire about arthropods rather than insects because it's a broader category, inclusive also of such charming non-insect invertebrates as ticks, centipedes, millipedes, and spiders. Asking a professional entomologist about arthropods (and not about, say, bugs) is.. David Quammen
191d14c weighing only five grams (about the same as two dimes), David Quammen
5fcb22a Acarologists (tick biologists) David Quammen
981b7ba Viruses face four basic challenges: how to get from one host to another, how to penetrate a cell within that host, how to commandeer the cell's equipment and resources for producing multiple copies of itself, and how to get back out--out of the cell, out of the host, on to the next. A David Quammen
7df3790 The protein wrap is known as a capsid. The David Quammen
3c0abfe Penicillin works by preventing bacteria from building their cell walls. So do its synthetic alternatives, such as amoxicillin. Tetracycline works by interfering with the internal metabolic processes by which bacteria manufacture new proteins for cell growth and replication. David Quammen
7f0f553 The basic point is so important I'll repeat it: RNA viruses mutate profligately. David Quammen
62d1349 ideas--and where facts were scarce, directive questions. Other David Quammen
57df76c Most bacteriologists were trained as medical men--Burnet himself had been, before going into bacteriological research--and "their interest in general biological problems was very limited." They cared about curing and preventing diseases, which was well and good; less so about pondering infection as a biological phenomenon, a relationship between creatures, equal in fundamental importance to such other relationships as predation, competition.. David Quammen
2230db1 A plate of Ebola virions mixed with Hendra virions would resemble capellini in a light sauce of capers. David Quammen
50a8569 equatorial Africa? Could it have arrived there in one soaring leap, leaving no traces in between? From southwestern Sudan to Manila is almost seven thousand miles as the bat flies. But no bat can fly that far without roosting. Are ebolaviruses more broadly distributed than we suspect? Should scientists start looking for them in India, Thailand, and Vietnam? Or did Reston virus get to the Philippines the same way Tai Forest virus got to Swit.. David Quammen
59e2f5a the good news about Reston virus, derived both from the 1989 US scare and from retrospective research on Luzon, is that it doesn't seem to cause illness in humans, only in monkeys. The bad news is that no one understands why. Apart David Quammen
e783a05 Why Big Fierce Animals Are Rare. David Quammen
6521848 Herpes B is a very rare infection in humans but a nasty one, with a case fatality rate of almost 70 percent among those few dozen people infected during the twentieth century (before recent breakthroughs in antiviral pharmaceutics) and almost 50 percent even since then. When David Quammen
68c638a Britain's Advisory Committee on Dangerous Pathogens had lately reclassified herpes B into biohazard level 4, placing it in the elite company of Ebola, Marburg, and the virus that causes Crimean-Congo hemorrhagic fever. National David Quammen
9e72811 Trophic cascades, as defined by Diamond in his "Rosetta Stone" paper, are the secondary effects that can ramify from level to level in consequence of a single extinction." David Quammen
6b2a4b2 convincing biologic evidence exists for symptomatic chronic B. burgdorferi infection in patients after recommended treatment regimens for Lyme disease. David Quammen
f250a5a No convincing biologic evidence exists for symptomatic chronic B. burgdorferi infection in patients after recommended treatment regimens for Lyme disease. David Quammen
433733b It worries the flu scientists because they know that H5N1 influenza is (1) extremely virulent in people, with a high lethality though a relatively low number of cases, and yet (2) poorly transmissible, so far, from human to human. It'll kill you if you catch it, very likely, but you're unlikely to catch it except David Quammen
ea06d72 RNA viruses because I already had that list in my mind: Hendra and Nipah, Ebola and Marburg, West Nile, Machupo, Junin, the influenzas, the hantas, dengue and yellow fever, rabies and its cousins, chikungunya, SARS-CoV, and Lassa, not to mention HIV-1 and HIV-2. All of them carry their genomes as RNA. The David Quammen
b4b3656 RNA viruses are limited to small genomes because their mutation rates are so high, and their mutation rates are so high because they're limited to small genomes. In fact, there's a fancy name for that bind: Eigen's paradox. Manfred Eigen is a German chemist, a Nobel winner, who has studied the chemical reactions that yield self-organization of longer molecules, a process that might lead to life. His paradox describes a size limit for such s.. David Quammen
39cc310 And hopefully nothing will happen." But of course, as she well knew, something always does happen. It's just a question of what and when." David Quammen
cd4b25e Among the most important things to remember about evolution--and about its primary mechanism, natural selection, as limned by Darwin and his successors--is that it doesn't have purposes. It only has results. To David Quammen
7b3be4b Saying no to the inevitable is one of the few precious ways our own species redeems itself from oblivion- or at least tries to. David Quammen
9ac03ae The order Chiroptera (the "hand-wing" creatures) encompasses 1,116 species, which amounts to 25 percent of all the recognized species of mammals. To say again: One in every four species of mammal is a bat. Such" David Quammen
fb9e2cb SIR model, representing a flow of individuals, during the course of an outbreak, through those three classes I mentioned earlier: from susceptible (S) to infected (I) to recovered (R). Anderson David Quammen
2fa12dc know that walking into a small woodlot," he wrote, "is riskier than walking into a nearby large, extensive forest." David Quammen
7b76817 Their result was a model-generated prediction: Given this rate of transmission, given that rate of recovery, given those unrelated mortalities, then . . . an intermediate grade of virulence should come to predominate. Son of a gun, it matched what had happened. David Quammen
44e561f One animal died and, after it tested positive for Reston virus, forty-nine others housed in the same room were "euthanized" as a precaution. (Most of those, tested posthumously, were negative.) Ten employees who had helped unload and handle the monkeys were also screened for infection, and they also tested negative, but none of them were euthanized." David Quammen
deed207 Appearances have enormous importance, Mr. Kessler. The creation and maintenance of appearances. Appearances govern. David Quammen
c148e18 Two men, on opposite sides of the world, had made the same great discovery at the same time. David Quammen
bf0960c What are they called? Sprackles, shakums, edible sequins, glossy sugar deedeebobs, I don't know. Instead of sprinkling them on a cookie, I sprinkle them on Angel de la Guarda. David Quammen
c4d8267 But here's a bit of spoilsport historical reality: It wasn't the finches that inspired Darwin, it was the Mockingbirds. David Quammen